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HIV-Related Neuropathy

HIV-associated sensory neuropathy: causes, treatment options including capsaicin patch, foot care and supportive care alongside ART.

Reviewed by Dr James Bristol, MD, PhDGuideline-basedStudies cited

Medically reviewed by Dr James Bristol, MD, PhD · Updated 2026-11-14

HIV-associated distal sensory polyneuropathy is the most common nerve problem in people living with HIV. It usually causes burning, numbness or pain in the feet. It can come from HIV itself or from some older HIV medicines (such as stavudine and didanosine), which are now rarely used.

Treatment

  • Keep taking your HIV treatment (ART) and talk to your HIV doctor about your symptoms; a medicine review may help
  • Check other causes: diabetes, B12, alcohol
  • A high-concentration capsaicin patch reduced pain in a controlled trial in HIV neuropathy (Simpson, 2008)
  • Other neuropathic pain medicines work less reliably in HIV neuropathy; your doctor can guide trials
  • Foot care, exercise and good footwear

Burning, numb or tingling feet for months? Get the free guide and a doctor review of your scan.

Supportive regenerative care

Regenerative approaches such as PRP or stem cells are early research for nerve symptoms. They do not treat or cure HIV and are considered only alongside your HIV specialist's care.

Find the cause

Diabetes, chemotherapy, HIV, B12 and more: treatment starts there.

Relieve the pain

Guideline medicines, capsaicin, exercise and foot care.

Explore what's next

PRP and stem cell research, with honest limits.

Related guides

Free guide · Step 1 of 2

Neuropathy relief: the 7-step plan for burning, numb or tingling nerves

What to check first, what helps day to day, which medicines guidelines recommend, and the newer regenerative options being studied. Free on WhatsApp.

Step 2 of 2

Last step: do you have nerve test results or a medical report?

If yes, a doctor reviews it for free and tells you whether regenerative or other non-surgical options could suit you.

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