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PRP Injections for Neuropathy

Perineural PRP for painful diabetic neuropathy: what the randomised trial found, who may benefit and what to expect.

Reviewed by Dr James Bristol, MD, PhDGuideline-basedStudies cited

Medically reviewed by Dr James Bristol, MD, PhD · Updated 2026-11-14

PRP (platelet-rich plasma) injected around nerves is being studied for painful diabetic neuropathy. A randomised trial (Hassanien, 2020) found patients who received perineural PRP reported less pain and better nerve test results than those on medicines alone. It is one small trial, so evidence is limited.

Who it may suit

  • Painful diabetic neuropathy not controlled by medicines
  • People looking for non-drug options

Burning, numb or tingling feet for months? Get the free guide and a doctor review of your scan.

What to expect

  • Blood drawn and spun to concentrate platelets
  • Ultrasound-guided injections around nerves in the leg
  • Effects, if any, build over weeks

PRP is sometimes combined with stem cell approaches. A doctor decides what could fit after reviewing your history.

Find the cause

Diabetes, chemotherapy, HIV, B12 and more: treatment starts there.

Relieve the pain

Guideline medicines, capsaicin, exercise and foot care.

Explore what's next

PRP and stem cell research, with honest limits.

Related guides

Free guide · Step 1 of 2

Neuropathy relief: the 7-step plan for burning, numb or tingling nerves

What to check first, what helps day to day, which medicines guidelines recommend, and the newer regenerative options being studied. Free on WhatsApp.

Step 2 of 2

Last step: do you have nerve test results or a medical report?

If yes, a doctor reviews it for free and tells you whether regenerative or other non-surgical options could suit you.

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